delayed neurocognitive recovery
Conditions
Interventions
Dexmedetomidine group (Group D):From the beginning of anesthesia induction to 30 minutes before the end of surgery, group D was pumped with dexmedetomidine 0.4 µ g / kg / h
Saline control group (Group C):From the beginning of anesthesia induction to 30 minutes before the end of surgery, group C was pumped with equal volume of 0.9% sodium chloride injection
Sponsors
First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. age >=18 years; 2. gastrointestinal tumor diagnosed and requiring laparoscopic surgery; 3. American Society of anesthesiologists (ASA) grade ? - ?; 4. voluntarily participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. preoperative presence of severe cerebrovascular disease that may affect the functional assessment of cerebral blood flow autoregulation (e.g., severe intracranial arterial stenosis, acute phase of cerebral infarction 180 mmHg or diastolic blood pressure > 110 mmHg); 9. patients on long-term use of a2-adrenergic agonists (e.g. colistin) or antagonists; 10. known hypersensitivity to dexmedetomidine or its preparatory excipients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of dNCR; | — |
Secondary
| Measure | Time frame |
|---|---|
| percentage of time with impaired CA;COX average;Incidence of dNCR;MMSE score;Incidence of POD;Resting and operating pain score;Recovery time of gastrointestinal function;Occurrence and incidence of major postoperative complications;postoperative adverse events; | — |
Countries
China
Contacts
Public ContactYatao Liu
First Hospital of Lanzhou University
Outcome results
None listed