Arteriosklerose
Conditions
Interventions
control group:normal saline
Treatment Group:the administration of Coenzyme I for Injection
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 40 and 70 years; 2.Abnormally elevated cf-PWV, exceeding the upper limit of the reference range matched for age and blood pressure; 3.Diagnosis of Grade 1 hypertension, with systolic blood pressure between 140 and 159 mmHg and/or diastolic blood pressure between 90 and 99 mmHg; 4.Willingness to participate and provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Consumption of foods or medications containing high levels of NAD+, NR, NAM, NMN, or niacin-related components (including vitamin B3 and natural health products) within 3 months prior to screening; 2.History of major cardiovascular or cerebrovascular events, including myocardial infarction, angina pectoris, stroke, or hospitalization for arterial revascularization; 3.Systolic blood pressure =160 mmHg and/or diastolic blood pressure =100 mmHg; 4.Diagnosis of malignant tumor; 5.Known allergy or severe adverse reactions to Coenzyme I for Injection or any of its components; 6.History of severe allergies or infusion reactions; 7.Pregnancy, lactation, or women planning pregnancy; 8.Severe hepatic or renal dysfunction: ALT or AST >5 times the upper limit of normal, or glomerular filtration rate =30 mL/min/1.73 m²; 9.Concurrent participation in another clinical trial without having completed the follow-up period; 10.Other conditions deemed by the investigator as unsuitable for inclusion in this study, such as psychiatric or psychological disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the change of endothelial function; | — |
Secondary
| Measure | Time frame |
|---|---|
| the change of degree of arterial stiffness; | — |
Countries
China
Contacts
Public ContactYi Zhang
Shanghai Tenth People's Hospital
Outcome results
None listed