Tic disorder
Conditions
Interventions
Health Control Group:None
Sponsors
Beijing Childrens Hospital,Capital Medical University
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for chronic tic disorder or Tourette syndrome as stipulated in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 2. Age 6-12 years old, gender not restricted, right-handed; 3. Able to tolerate MEG examination, without any clear contraindications for MEG examination (such as the presence of non-antimagnetic metal implants in the body), head circumference = 55 cm; 4. Guardians and the subjects (if capable) sign the informed consent form after fully understanding the content.
Exclusion criteria
Exclusion criteria: 1.With severe or unstable physical or mental illnesses, such as cardiac, hepatic, or renal insufficiency; hematological diseases; autoimmune disorders; inherited metabolic diseases; epilepsy; schizophrenia; etc. 2.Comorbid with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), other neurodevelopmental disorders, as well as affective disorders such as anxiety disorders, depressive disorders, and obsessive-compulsive disorder (OCD). 3.With sensory organ deficits (such as hearing or vision impairment) or cognitive dysfunction, resulting in inability to cooperate with the research tasks. 4.Have taken medications that may significantly affect the central nervous system within 4 weeks prior to enrollment, such as antipsychotics, CNS stimulants, antidepressants, sedative-hypnotics, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MEG characteristic indicators (resting-state neural oscillation power spectral density and functional connectivity values; event-related field latency and amplitude; post-stop-signal power changes); | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event records;Clinical scale assessments (Yale Global Tic Severity Scale, Premonitory Urge for Tics Scale, etc) and task-based behavioral metrics.; | — |
Countries
China
Contacts
Public ContactWeiZhang;Guojun Zhang
Beijing Childrens Hospital,Capital Medical University
Outcome results
None listed