Space occupying lesion of the liver
Conditions
Interventions
Remimazolam high-dose group:During the maintenance of anesthesia, patients in this group were infused with remimazolam at 0.4 mg/kg/h.
Remimazolam low-dose group:During the maintenance of anesthesia, patients in this group were infused with remimazolam at 0.2 mg/kg/h.
Control group:In the control group, 0.9% saline was intravenously infused at same volume and rate.
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with liver mass lesions undergoing elective partial liver resection under general anesthesia, regardless of gender; 2. Age > 18 years; 3. BMI 18 - 28 kg/m^2; 4. American Society of Anesthesiologists (ASA) classification II - III; 5. Child-Pugh classification A; 6. Voluntary participation in this study and signing of informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe heart, lung or kidney diseases, congenital liver diseases or autoimmune liver diseases before the operation; 2. Those who have been using sedative and analgesic drugs for a long time; 3. Long-term alcohol abusers or those with a recent history of heavy drinking; 4. Those who are allergic to remimazolam or propofol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The serum AST, ALT, LDH, TBIL and ALB levels.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The levels of inflammation biomarkers;Types and dosages of vasoactive drugs;Hemodynamic data;The levels of liver biomarkers on one month after surgery;Types and dosages ofanesthetics;Postoperative complications; | — |
Countries
China
Contacts
Public ContactTianxiao Liu
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed