Dry eye
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: ubjects aged between 18 and 70 years are eligible for inclusion if they meet the following key criteria: participants must simultaneously satisfy the diagnostic criteria for dry eye disease (DED) and meibomian gland dysfunction (MGD). Diagnostic criteria for DED used in this study were based on the Chinese Expert Consensus on Dry Eye Disease [9,10]: 1 Visual Surface Disease Index (OSDI) >= 13; fluorescein tear film break-up time (FBUT) = 13; and 5 s = 5 spots. Diagnostic criteria for MGD used in this study were based on the International Workshop on Meibomian Gland Dysfunction standards [11]: abnormal meibomian gland orifices (e.g., blockage, narrowing, or posterior displacement); altered secretion quality (e.g., cloudy, granular, or inspissated/toothpaste-like material); or meibomian gland dropout (confirmed by meibomian gland imaging).
Exclusion criteria
Exclusion criteria: history of ocular surgery and laser treatment within 3 months; use of topical eye drops for the within 3 months; use of systemic medications affecting DED or contact lens wear within 3 months; abnormalities in the cornea, conjunctiva or eyelid; any systemic diseases associated with MGD or DED.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FBUT; | — |
Secondary
| Measure | Time frame |
|---|---|
| LLT;Meibomian gland evaluation; | — |
Countries
China
Contacts
Tianjin medical university eye hospital