Clinically, NPPK primarily presents as well-demarcated, diffuse erythema and non-mutilating hyperkeratosis on the palms and soles. A characteristic finding is the development of whitish swelling upon exposure to water. The lesions may extend beyond the palmar-plantar regions to the dorsal aspects of the hands and feet, the flexor wrists, ankles, and Achilles tendon areas. Involvement of the elbows
Conditions
Interventions
Observation group:None
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Regardless of age or sex; 2.Patients with a confirmed diagnosis of NPPK and their families who participate in the information collection and verification for this project; 3.The patient or their legal guardian understood the nature of the study and signed the informed consent form (ICF). In cases where the patient was unable to sign, the form was signed by their legal guardian.
Exclusion criteria
Exclusion criteria: 1.NO;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of participants with pathogenic SERPINB7 mutations; | — |
Countries
China
Contacts
Public ContactWeilong Zhong
Peking University Shenzhen Hospital
Outcome results
None listed