Urology disease that require surgery
Conditions
Interventions
data collection for model establishment (general anesthesia with muscle relaxants):None
model validation (general anesthesia, and using muscle relaxants according to modeling and stimulation):None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.urology surgical patients, age 18 ~ 85; 2.surgery duration >= 20 min; 3.general anesthesia, using nondepolarizing neuromuscular blocking agents (muscle relaxants); 4.capable of handgrip strength test, feasible for intra-operative TOF (train of four) monitoring; 5.Capable of understanding the study protocol and procedures, willingness to comply with all study requirements, and voluntary provision of written informed consent;
Exclusion criteria
Exclusion criteria: 1.intra-operative massive hemorrhage, severe shock, or situations that obviously disturb drug effects and elimination of drugs; 2.intra-operative blood transfusion; 3.absence of TOF monitoring data; 4.change the type of anesthesia into non-general anesthesia, or general anesthesia without muscular relaxants; 5.failure of blood sample collection resulting in multiple plasma drug concentration absence/missing; 6.other situations considered unsuitable for participation by researchers;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pharmacodynamic effects;plasma concentration of muscle relaxants; | — |
Secondary
| Measure | Time frame |
|---|---|
| hand grip strength;muscle relaxants related adverse events; | — |
Countries
China
Contacts
Public ContactYinQinqin
West China Hospital of Sichuan University
Outcome results
None listed