Chronic apical periodontitis
Conditions
Interventions
Group A:None
Group B:None
Sponsors
Stomatology Hospital,Zhejiang University School Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Clinical examination and imaging data (periapical radiographs, CBCT) confirmed the diagnosis of pulp necrosis in young permanent teeth (with or without apical periodontitis or periapical abscess), with clear indications for pulp revascularization therapy; 2. Patients who received and completed standardized pulp revascularization therapy in the Department of Conservative Dentistry and Endodontics at Zhejiang Provincial Stomatological Hospital for the first time between January 1, 2015, and December 2025; 3. Condition of the teeth: the affected teeth are young permanent teeth with incompletely developed roots (Cvek stages 1-4 or Nolla stages 6-9); 4. Data completeness: preoperative data must include complete medical history records, clear and assessable baseline periapical radiographs, and CBCT imaging data meeting research analysis quality requirements (DICOM format); postoperative data must include at least 12 months of regular, standardized clinical and imaging follow-up records, allowing evaluation of the efficacy outcomes set in this study (such as apical healing and root development maturation); for patients involving intracanal microbiota data, intraoperative root canal samples must be collected according to standardized procedures, and qualified microbiological test data must be available; demographic information and key treatment-related indicators must be fully recorded.
Exclusion criteria
Exclusion criteria: 1. Incomplete/irregular treatment: Failure to complete the entire treatment procedure of pulp revascularization, or treatment plans that significantly deviate from standardized guidelines; 2. Poor tooth condition: The affected tooth has severe loss of tooth structure that prevents adequate coronal sealing. The affected tooth has extensive internal or external root resorption (e.g., exceeding one-third of the root length), root perforation, longitudinal root fracture, or root fracture involving the middle third or less, making it unsuitable for revascularization; 3. General health conditions: Presence of systemic diseases that severely affect immune function or tissue healing (e.g., uncontrolled diabetes, hematologic disorders, malignant tumors undergoing radiotherapy or chemotherapy, AIDS, etc.); long-term use of drugs that may significantly affect pulp or bone healing (e.g., bisphosphonates, high-dose corticosteroids, immunosuppressants, etc.); 4. Inadequate data: Severe missing, heavily artifact-affected, or low-quality preoperative or postoperative key clinical data, imaging data (periapical radiographs, CBCT), microbiological samples, etc., making it impossible to meet the requirements for data extraction, quantification, and analysis in this study; 5. Concomitant treatment interference: During the pulp revascularization treatment period or follow-up, the study tooth received other dental treatments that could significantly interfere with independent evaluation of therapeutic efficacy; 6. Loss to follow-up: Unable to obtain at least 12 months of valid follow-up data; 7. Previous treatment history: The study tooth has undergone other pulp treatments (e.g., partial pulpotomy).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Follow-up indicators of affected teeth;Bacteria in the root canal; | — |
Countries
China
Contacts
Public ContactYuan Wang
Stomatology Hospital,Zhejiang University School Medicine
Outcome results
None listed