Autism Spectrum disorder
Conditions
Interventions
Observation group:None
Control group:None
Sponsors
Wenling Maternal and Child Health Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Children aged between 2 and 8 years who have previously been diagnosed with ASD, or who are diagnosed with ASD by senior specialists from the research team according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), exhibiting social interaction deficits, communication difficulties, repetitive and stereotyped behaviors, developmental abnormalities, etc.; 2. The ADOS-2 Autism Diagnostic Observation Schedule is chosen as the main auxiliary diagnostic tool, and ADOS-2 is currently considered the "gold standard" for clinical diagnosis of autism in children both domestically and internationally; 3. The primary caregiver or parents agree to participate in the study, complete relevant specimen collection, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Children with congenital diseases or chromosomal abnormalities; 2. Children with other neurodevelopmental disorders such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, or selective mutism; 3. Children with immune system or hematological dysfunction, or those with heart, liver, or kidney insufficiency; 4. Children with organic gastrointestinal diseases, acute gastrointestinal diseases, or infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of 5-HT levels in children's blood, detection of 5-HT in feces, and analysis of intestinal flora structure;Collection of biological specimens for experimental animals and behavioral testing; | — |
Secondary
| Measure | Time frame |
|---|---|
| General clinical information (general demographic information of the children, maternal exposure to toxic drugs during pregnancy, delivery method, dietary preferences, sleep problems, feeding methods, the severity of social communication impairments in children with autism, repetitive stereotyped behaviors, gastrointestinal function impact, degree of social support, and social adaptation ability); | — |
Countries
China
Contacts
Public ContactShuhong Zheng
Wenling Maternal and Child Health Hospital, Zhejiang Province
Outcome results
None listed