Colorectal cancer
Conditions
Interventions
Photon-Counting CT (for Diagnosis of Regional Lymph Node Metastasis):Determination of Colon Cancer TN Staging with Photon-Counting CT
Energy-Integrating Detector CT (for Diagnosis of Regional Lymph Node Metastasis):Determination of Colon Cancer TN Staging with Energy-Integrating Detector CT
Photon-Counting CT (for Evaluation of Neoadjuvant Therapy Efficacy for Rectal Cancer):Evaluation of Neoadjuvant Therapy Efficacy for Rectal Cancer Using Photon-Counting CT
Photon-Counting CT (3D Reconstruction of Mesenteric Vessels and Surgical Navigation):3D Reconstruction of Mesenteric Vessels and Surgical Navigation Using Photon-Counting CT
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: I. Diagnosis of Regional Lymph Node Metastasis in Colon Cancer by PCCT (1) Aged 18–80 years; (2) Colon adenocarcinoma confirmed by pathological biopsy, with colonoscopy showing that the lesion is at least = 10 cm from the anal margin; (3) Informed consent of subjects. II. Diagnosis of Rectal Cancer Staging and Evaluation of Neoadjuvant Therapy Efficacy by PCCT (1) Aged 18–80 years; (2) Pathologically confirmed rectal adenocarcinoma; (3) Middle-low rectal cancer, with colonoscopy showing that the lower edge of the tumor is = 10 cm from the anal margin; (4) Informed consent of subjects. III. Three-Dimensional Reconstruction of Mesenteric Vessels and Surgical Navigation by PCCT (1) Aged 18–80 years; (2) Pathologically confirmed colon adenocarcinoma; (3) Colonoscopy showing that the tumor is expected to be located in the right colon; (4) Informed consent of subjects.
Exclusion criteria
Exclusion criteria: I. Diagnosis of Regional Lymph Node Metastasis in Colon Cancer by PCCT (1) Previous history of colectomy; (2) Multiple primary colorectal cancers; (3) Clinically confirmed distant metastasis after imaging assessment; (4) Clinically confirmed indication for neoadjuvant therapy after imaging assessment; (5) Emergency surgery performed due to tumor obstruction or bleeding; (6) Comorbidity with inflammatory bowel disease, intestinal or abdominal tuberculosis, or other infectious diseases (or history of such diseases); (7) Additional radical surgery performed after endoscopic resection; (8) Contraindications to contrast-enhanced CT examination (e.g., contrast agent allergy, renal insufficiency, etc.); (9) Failure to undergo radical surgical resection (e.g., poor physical status, peritoneal metastasis detected during intraoperative exploration, etc.); (10) History of other active malignant tumors within the past 5 years. II. Diagnosis of Rectal Cancer Staging and Evaluation of Neoadjuvant Therapy Efficacy by PCCT (1) No neoadjuvant therapy received; (2) Multiple primary colorectal cancers; (3) Clinically confirmed distant metastasis after imaging assessment; (4) Emergency surgery performed due to tumor obstruction or bleeding; (5) Comorbidity with inflammatory bowel disease, intestinal or abdominal tuberculosis, or other infectious diseases (or history of such diseases); (6) Contraindications to contrast-enhanced CT or rectal MRI examination; (7) History of other active malignant tumors within the past 5 years. III. Three-Dimensional Reconstruction of Mesenteric Vessels and Surgical Navigation by PCCT (1) Tumor confirmed by CT not located in the right colon (from the ileocecal junction to the right one-third of the transverse colon); (2) Contraindications to contrast-enhanced CT examination; (3) Failure to undergo radical surgical resection; (4) History of other active malignant tumors within the past 5 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The sensitivity of PCCT in diagnosing lymph node staging of colon cancer (Diagnosis of Regional Lymph Node Metastasis);Relationship Between PCCT Lesion Iodine Concentration and Tumor Rregression Grade (Evaluation of Neoadjuvant Therapy Efficacy);Sensitivity of PCCT Vascular 3D Reconstruction in Determining Gastrocolic Trunk Classification (for Mesenteric Vascular 3D Reconstruction and Surgical Navigation); | — |
Secondary
| Measure | Time frame |
|---|---|
| The diagnostic efficacies of PCCT in diagnosing TN staging of colon cancer (Diagnosis of Regional Lymph Node Metastasis);Imaging characteristics differences of metastatic and non-metastatic lymph nodes (Diagnosis of Regional Lymph Node Metastasis);Relationship Between PCCT Lesion Iodine Concentration and Clinicopathological Indicators (Evaluation of Neoadjuvant Therapy Efficacy); | — |
Countries
China
Contacts
Public ContactXiao Yi
Peking Union Medical College Hospital
Outcome results
None listed