Hip replacement
Conditions
Interventions
Low dose group:Before anesthesia induction, administer liposomal bupivacaine for iliac fascia block: liposomal bupivacaine 133 mg with 20 mL of 0.9% saline = 30 mL
High-dose group:Before anesthesia induction, administer a fascia iliaca block with liposomal bupivacaine: Liposomal bupivacaine 266 mg in 10 mL of 0.9% saline = 30 mL
Ropivacaine group:Administer ropivacaine for iliac fascia block before anesthesia induction: 1% ropivacaine 100 mg + 0.9% saline 20 mL = 30 mL
Sponsors
The First Affiliated Hospital of Anhui University of Science and Technology
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 65 and 80 years, no gender restriction; 2. Patients classified as ASA I~III by the American Society of Anesthesiologists; 3. Patients who are informed, voluntarily participate in the clinical trial, and have signed the Informed Consent Form for Clinical Trials; 4. Patients who are able to actively cooperate with medical staff.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cognitive impairment who cannot cooperate with an iliac fascia block; 2. Severe coagulation disorders; 3. History of allergy to local anesthetics; 4. Presence of infection, nerve injury, or other issues at the puncture site; 5. Severe cardiovascular or pulmonary disease; 6. Surgery duration longer than 3 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative resting and movement Numerical Rating Scale (NRS) pain intensity score area under the curve (AUC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical indicators: C-reactive protein, erythrocyte sedimentation rate, interleukin-6, cortisol, and malondialdehyde;Total consumption of opioids;Number of rescue analgesia doses and time to first rescue analgesia;Postoperative muscle strength recovery: Assessment of quadriceps strength using an electronic dynamometer and the 30-second chair stand test;Bupivacaine levels in the blood samples of patients after iliac fascia block;Monitor and record any adverse events and postoperative complications (opioid-related side effects such as nausea, vomiting, and itching, as well as potential cardiac and neurotoxic side effects);Record the length of hospital stay and the postoperative quality of life and satisfaction of patients; | — |
Countries
China
Contacts
Public ContactLiu Minghong
The First Affiliated Hospital of Anhui University of Science and Technology
Outcome results
None listed