Post-liver transplantation status
Conditions
Interventions
Immunosuppression Minimizition /Elimination Group:Three-stage Immunosuppression Minimizition /Elimination (Hep-TIME) Strategy
Sponsors
The First Hospital of Jilin University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age over 18 years; 2. More than 3 years after liver transplantation; 3. Maintenance therapy using only tacrolimus and/or sirolimus; 4. Medication dose less than 2 mg and drug concentration less than 5.0 ng/ml; 5. No rejection episodes in the past year; 6. Primary disease is not autoimmune hepatitis; 7. Liver biopsy confirms no subclinical rejection or significant fibrosis changes; 8. No active HBV or HCV infection; 9. No plans for pregnancy; 10. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Combined organ transplantation, ABO-incompatible liver transplantation, living donor liver transplantation, and secondary (multiple) liver transplantation; 2. With active infections; 3. With vascular or biliary complications; 4. With recurrent or new tumors; 5. Unable to follow up on time; 6. Having other diseases that require the use of immunosuppressants; 7. Drug or alcohol abuse; 8. Accompanied by other unstable chronic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune elimination success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-year survival rate;Immune minimization success rate;Immune minimization failure rate;Alleviation of immunosuppressant-related adverse effects;Graft loss rate; | — |
Countries
China
Contacts
Public ContactQiu Wei
The First Hospital of Jilin University
Outcome results
None listed