stroke
Conditions
Interventions
Group A:1 Hz iTIS over the contralesional Corpus callosum area(CC) and then 10HZ stimulation over the ipsilesional Corpus callosum area
Group B:contralesional sham stimulation and then 10HZ stimulation over the ipsilesional CC
Group C:contralesional real 1 Hz iTIS and then ipsilesional sham stimulation
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with first-onset ischemic stroke; 2. Patients with acute stroke within 2 weeks; 3. Patients with unilateral limb motor dysfunction; 4. Patients with cerebral infarction in the unilateral middle cerebral artery area as indicated by magnetic resonance imaging (MRI); 5. Patients aged between 18 and 80 years old; 6. Patients identified as right-handed based on the Edinburgh Handedness Inventory; 7. Patients with normal auditory function; 8. Patients capable of completing 30 minutes of daily rehabilitation training as required; 9. Patients who have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with hemorrhagic stroke; 2. Patients with other neurological disorders; 3. Patients with severe aphasia or cognitive impairment; 4. Patients who are about to receive or have already received antidepressant or benzodiazepine treatment; 5. Patients with concurrent cancer, severe lung disease or heart disease; 6. Patients with contraindications to MR, including pacemaker implantation or epilepsy; 7. Those who cannot provide informed consent; 8. Patients who refuse to participate, die or are lost to follow-up during the follow-up period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment(FMA); | — |
Secondary
| Measure | Time frame |
|---|---|
| A multi-modal fMRI data;National Institutes of Health Stroke Scale(NIHSS);Modified Rankin Scale(mRS);Magnetic Resonance Spectroscopy(MRS); | — |
Countries
China
Contacts
Public ContactQingmei Chen
Department of Rehabilitation Medicine, the First Affiliated Hospital of Soochow University
Outcome results
None listed