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A prospective randomized controlled trial on the preventive effect of titrated pressor drugs based on fingertip pulse oximetry waveform on hypotension after cesarean section spinal anesthesia

Photoplethysmography Waveform-Guided Vasopressor Titration for Prevention of Hypotension during Cesarean Delivery under Spinal Anesthesia: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600116138
Enrollment
Unknown
Registered
2026-01-06
Start date
2026-01-31
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative complications

Interventions

observation group:No
control group:Immediately after spinal anesthesia, administer epinephrine infusion. After the occurrence of hypotension, administer epinephrine for treatment.
Pulse Oxygen Warning Group:Immediately after spinal anesthesia, administer epinephrine infusion. Before hypotension occurs, give epinephrine based on the pulse wave. After hypotension occurs, administ

Sponsors

Shanghai Fengxian District Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: (1) American Society of Anesthesiologists (ASA) physical status class I-II. (2) Age 20-45 years. (3) Body weight 50-90 kg, height 150-180 cm, body mass index (BMI) 18-28 kg/m². (4) Full-term singleton pregnancy, scheduled for cesarean section.

Exclusion criteria

Exclusion criteria: (1) There is spinal deformity; (2) Complicated with severe cardiovascular and cerebrovascular diseases, neurological disorders, and coagulation dysfunction; (3) Multiple pregnancies; (4) Estimated fetal weight is lower than 2.5 kg or higher than 4.0 kg; (5) The researchers judged that the participants were not suitable to participate in this study or the subjects were unwilling to cooperate.

Design outcomes

Primary

MeasureTime frame
The incidence of hypotension;

Secondary

MeasureTime frame
The incidence rate of nausea and vomiting;Lower extremity Doppler ultrasound spectrum;Pulse waveform change rate;change rate of heart beat;Apgar score;Cerebral oxygen saturation;Hemodynamic indicators (SV, CO, SVR);Umbilical cord blood gas analysis;

Countries

China

Contacts

Public ContactHuang Dingding

Shanghai Fengxian District Central Hospital

huangdingding1984@163.com+86 180 1882 0343

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026