Emergence Agitation
Conditions
Interventions
Remazolam group:Anesthetic maintenance with remimazolam
Propofol group:Anesthetic maintenance with propofol
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-65 years old; 2.ASA I-II grade; 3.BMI: 18-30kg/m^2 4. The estimated duration of the operation is about 1 hour. 5. Preoperative airway assessment is acceptable, and it is expected that there is no risk of difficult ventilation or difficult intubation. 6. Good basic oxygenation: At rest, the pulse oxygen saturation when breathing air is >=96%. 7. Informed consent of the subjects.
Exclusion criteria
Exclusion criteria: 1. Have a history of mental illness or frequently take psychotropic drugs; 2. There were severe organic lesions in the heart or brain before the operation; 3. Allergy to propofol or benzodiazepines; 4. Inability to communicate due to hearing or language impairments; 5. Preoperative heart rate less than 50 beats per minute or second-degree or above atrioventricular block; 6. Possessing diseases that are prone to causing respiratory depression, such as chronic obstructive pulmonary disease, asthma, and sleep apnea syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emergence Agitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients with different agitation scores and the highest agitation score recorded;Pain score;Time to emergence;Extubation time;Anxiety score;Sleep quality score;Nausea and vomiting;Adverse events;Quality of Recovery score (QoR score);Anesthesia satisfaction; | — |
Countries
China
Contacts
Public ContactJianhui Liu
Shanghai Tongji Hospital
Outcome results
None listed