Esophageal cancer
Conditions
Interventions
Control Group (Normal Saline Group) :Postoperative PCIA Analgesia (Sufentanil + Ondansetron + Normal Saline)
Experimental Group 1 (Esketamine 2mg/kg Group) :Postoperative PCIA Analgesia (Sufentanil + Ondansetron + Esketamine 2mg/kg)
Experimental Group 2 (Esketamine 3mg/kg Group) :Postoperative PCIA Analgesia (Sufentanil + Ondansetron + Esketamine 3mg/kg)
Experimental Group 3 (Esketamine 4mg/kg Group) :Postoperative PCIA Analgesia (Sufentanil + Ondansetron + Esketamine 4mg/kg)
Sponsors
Anhui Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 60 to 80 years old, gender not limited; 2.ASA Grade II - III; 3.BMI: 18-30 kg/m ² 4. The patient or (and) the family members request to undergo thoracoscopic and laparoscopic surgery for esophageal cancer under general anesthesia; 5. Be able to understand and voluntarily sign the informed consent form, and be willing to abide by the requirements of the trial protocol.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to or contraindicated to benzodiazepines, opioids, propofol, flumaciclib, naloxone, ketamine and their drug components; 2. Patients with severe heart, lung or kidney insufficiency, combined with multiple chronic diseases who cannot tolerate surgical anesthesia, as well as those with mental disorders; 3. Those with increased intracranial or intraocular pressure; 4. Those with a history of alcohol abuse, opioid allergy or abuse of such drugs; 5. Patients with uncontrolled severe hypertension; 6. Other circumstances that the researcher deems unsuitable for enrollment; 7. People who have had neurological diseases or undergone surgery recently.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score (rest/cough) ;MMSE score ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative PCIA pressing times ;Serum IL-6 level ; | — |
Countries
China
Contacts
Public ContactTang Chaoliang
Anhui Provincial Cancer Hospital
Outcome results
None listed