Hemodynamic instability
Conditions
Interventions
Fospropofol Disodium Group:During anesthetic induction, fospropofol disodium was administered intravenously by slow injection at a dose of 12 mg/kg over 60 seconds until the bispectral index (BIS) dec
Propofol Group:During anesthetic induction, propofol was administered intravenously by slow injection at a dose of 1.5 mg/kg over 30 seconds until the bispectral index (BIS) decreased to 40–60. This w
Sponsors
Fuyang People’s Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years, any gender; 2. ASA classification II–III; 3. Planned elective unilateral total knee arthroplasty to be performed under general anesthesia; 4. Preoperative assessment shows no severe heart, lung, liver, or kidney dysfunction, and the patient can tolerate general anesthesia; 5. The participant and their family voluntarily agree to participate in the study and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe respiratory or circulatory system diseases, such as NYHA class III or above, recent (within 3 months) myocardial infarction, chronic respiratory failure, or active pulmonary infection; 2. Severe liver or kidney dysfunction (ALT or AST > 3 times the upper limit of normal, or eGFR < 45 mL/min/1.73 m²); 3. Comorbid cerebrovascular or neurological diseases (such as Parkinson's disease, epilepsy, etc.) that may affect anesthesia assessment; 4. Allergy to propofol, fospropofol disodium, or related substances (including lecithin, soy products, etc.); 5. Use of beta-blockers, lidocaine, or other medications that affect circulatory stability and cannot be discontinued; 6. Severe preoperative anemia (Hb < 90 g/L) or hypovolemic state; 7. History of drug abuse; 8. Other conditions that the researcher deems unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hemodynamic instability events; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of individual hemodynamic instability events;The incidence of drug-related adverse events;Pain scores and analgesic requirements; | — |
Countries
China
Contacts
Public ContactXiaofeng Wang
Fuyang People’s Hospital
Outcome results
None listed