Psoriasis
Conditions
Interventions
Experimental Group: Apply 5 mL of Bifidobacterium adolescentis solution to psoriatic lesions on the limbs daily for a duration of 2 months.
Control Group: Apply 5 mL of heat-inactivated Bifidobacterium adolescentis solution to psoriatic lesions on the limbs daily for a duration of 2 months.
Placebo Control Group: Apply 5 mL of normal saline to psoriatic lesions on the limbs daily for a duration of 2 months.
Sponsors
Shenzhen People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: PASI score (Psoriasis Area and Severity Index) < 10 (indicating mild to moderate disease) with psoriatic lesions present on the limbs; Provision of written informed consent and voluntary participation; Age between 18 and 60 years, in generally good health; No use of any psoriasis-related medications within the past 6 months; Absence of local infection or neuromuscular diseases.
Exclusion criteria
Exclusion criteria: Patients with no psoriatic lesions on the limbs, other types of psoriasis (e.g., pustular, erythrodermic, or arthropathic), or severe psoriasis (typically defined as PASI score = 10 or BSA = 10%); Patients with active concurrent skin diseases or severe comorbidities; Any other condition that, in the investigator's judgment, would render the participant unsuitable for the study (e.g., deemed unreliable, or unable/unwilling to comprehend or adhere to study procedures and assessments).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Trans Epidermal Water Loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical photography;Dermoscopic imaging; | — |
Countries
china
Contacts
Public ContactJianglin Zhang
Shenzhen People’s Hospital (The First Affiliated Hospital of Southern University of Science and Technology; The Second Clinical Medical College of Jinan University)
Outcome results
None listed