Colon cancer
Conditions
Interventions
Dexmedetomidine Group:Dexmedetomidine
Remimazolam Group:Remimazolam
Sponsors
Army Medical Center of PLA
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients scheduled to undergo elective laparoscopic colon cancer surgery under general anesthesia; 2.American Society of Anesthesiologists (ASA) physical status classification: I–III; 3.Age: >=18 years; 4.Body mass index (BMI): 18–30 kg/m^2; 5.Normal cognitive function; 6.Expected operative duration: 1–6 h; 7.Written informed consent provided.
Exclusion criteria
Exclusion criteria: 1.Known allergy to the investigational drugs; 2.History of severe cardiac (second- or third-degree atrioventricular block or baseline heart rate <50 beats/min), hepatic (Child–Pugh class C), or renal dysfunction (requiring renal replacement therapy); 3.Preexisting gastrointestinal dysfunction before surgery (intestinal obstruction or inflammatory bowel disease); 4.Previous history of abdominal surgery. 5.Planned or unplanned perioperative stoma creation; 6.Conversion from laparoscopic to open surgery; 7.Inability to complete extubation in the operating room, requiring transfer to the ICU with an endotracheal tube in place; 8.No use of postoperative patient-controlled analgesia (PCA).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first flatus after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Gastrointestinal Function (I-FEED) Score;The quality of recovery in the first three postoperative days was assessed using the QoR-15 Score.;Incidence of Perioperative Adverse Events;Intestinal Function Recovery Rate at 72 Hours Postoperatively;Time to first oral intake postoperatively;Perioperative Opioid Consumption; | — |
Countries
China
Contacts
Public ContactQingxiang Mao
Army Medical Center of PLA
Outcome results
None listed