Midline anterior skull base pathologies
Conditions
Interventions
High-flow / 3-day bed-rest group:Mandatory absolute bed rest for 3 days post-operatively
Low-flow / 2-day bed-rest group:Mandatory absolute bed rest for 2 days post-operatively
Low-flow / non-bed-rest group:No mandatory absolute bed-rest period after surgery
High-flow / 1-day bed-rest group:Mandatory absolute bed rest for 1 day post-operatively
Sponsors
The Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Male and female patients aged 18 to 75; 2. An endoscopic transnasal midline anterior skull base surgery is planned, but cerebrospinal fluid leakage may occur during the operation. 3. The patient was conscious before the operation and had normal limb movement, and could cooperate with postoperative bed and non-bed treatment. 4. There are no severe cardiopulmonary dysfunction or other complications that affect the tolerance to general anesthesia and surgery. 5. The patient has good compliance, voluntarily participates in this clinical study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pre-existing bed-rest–related complications such as hypostatic pneumonia, lower-extremity venous thrombosis, or pressure ulcers. 2.Anticipated requirement for prolonged post-operative bed rest. 3.No cerebrospinal fluid leakage occurred during surgery, or dural defect extending beyond the midline anterior skull-base region. 4.Any other condition that, in the investigator’s opinion, renders the participant unsuitable for enrollment. 5.Patients with poor treatment compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skull base reconstruction success rate within 1 month postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of bed-rest related postoperative events during hospitalization;Postoperative quality-of-life score;Postoperative length of stay and treatment cost; | — |
Countries
China
Contacts
Public ContactJiang Yan
The Affiliated Hospital of Qingdao University
Outcome results
None listed