Pre-acute-on-chronic liver failure
Conditions
Interventions
Bone marrow mesenchymal stem cell treatment group:CG-BM1 allogeneic human bone marrow mesenchymal stem cell injection
Standardized drug treatment group:CG-BM1 allogeneic human bone marrow mesenchymal stem cell injection
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18 to 60 years old; 2. Meet the pre-diagnosis criteria for liver failure as stipulated in the "Guidelines for the Diagnosis and Treatment of Liver Failure (2024 Edition)" : 1) Extreme fatigue, accompanied by obvious anorexia, vomiting, abdominal distension and other severe digestive tract symptoms; 2) Significant increase in ALT and/or AST, progressive deepening of jaundice (85.5µmol/L = 17.1µmol/L; There is a bleeding tendency, 40% < PTA <= 50%(PT INR < 1.5). 3. The subjects voluntarily participated in this study and have signed the informed consent form by themselves or their guardians.
Exclusion criteria
Exclusion criteria: 1.Pregnancy, preparation for pregnancy or lactation; 2.Individuals with neurological or psychiatric disorders who are unable to cooperate or unwilling to cooperate; 3.Severe chronic non-liver organ failure; 4.Untreated HIV infection; 5.Infection with hemodynamic instability; 6.Diagnosed hepatocellular carcinoma or other malignant tumors of organs during screening; 7.Previously participated in clinical trials on stem cells; 8.Participants who are currently participating in other clinical trials or have participated in other clinical trials within 3 months; 9.Not willing to sign informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rates at day 90; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rates of ACLF at Day 28; | — |
Countries
China
Contacts
Public ContactHe Yingli
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed