Helicobacter pylori infection
Conditions
Interventions
14-day quadruple therapy:Omeprazole 20 mg BID + Amoxicillin 1 g BID + Clarithromycin 500 mg BID + Bismuth agent 200 mg BID
Modified Vonoprazan Combined with High-Dose Amoxicillin Dual Therapy:Vonoprazan 20 mg BID + Amoxicillin 1 g TID for 10 days
Sponsors
Qinghai Provincial Xining Third People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 to 75 years, inclusive, regardless of gender. 2. Positive test result: A positive ¹³C- or ¹4C-urea breath test result within one month prior to enrollment. 3. Diagnosis and indication: Patients diagnosed with Helicobacter pylori-positive chronic gastritis by gastroscopy within three months, who meet the criteria for H. pylori eradication as recommended by the Sixth Chinese National Consensus Report on the Management of Helicobacter pylori Infection, and are willing to undergo eradication therapy. 4. Treatment-naïve: No prior history of H. pylori eradication therapy. 5. Informed consent: Signed informed consent form must be obtained.
Exclusion criteria
Exclusion criteria: Patients allergic to any of the study drugs. 2. Patients who have used Vonoprazan (or other PCABs), PPIs, H2-receptor antagonists, antibiotics, bismuth agents, or probiotic preparations within one month prior to treatment initiation. 3. Pregnant or lactating women, or patients planning pregnancy during the study period. 4. Patients requiring use of NSAIDs, adrenal corticosteroids, or anticoagulants during the study period. 5. Patients with severe concurrent diseases that may interfere with the study evaluation, such as cardiac, pulmonary, hepatic, renal, metabolic, or psychiatric diseases, or malignant tumors. 6. Patients with a history of gastric or esophageal surgery. 7. Patients unlikely to complete follow-up or with other factors that may compromise compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Compliance; | — |
Countries
China
Contacts
Public ContactAng Cheng
Qinghai Provincial Xining Third People's Hospital
Outcome results
None listed