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Clinical Guiding Value of Targeted Sequencing of Blood Microorganisms in Febrile Patients with Malignant Tumors

Clinical Guiding Value of Targeted Sequencing of Blood Microorganisms in Febrile Patients with Malignant Tumors

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600116001
Enrollment
Unknown
Registered
2026-01-04
Start date
2025-11-29
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer

Interventions

Retrospective case analysis of patients with malignant tumors and fever detected by conventional methods.:None
Malignant tumor patients presenting to the emergency department with fever as the primary presenting symptom.:None

Sponsors

Cancer Hospital, Chinese Academy of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1 Inclusion Criteria for the Experimental Group (1) Patients confirmed as malignant tumor cases by pathology or cytology; (2) Presence of fever with a body temperature > 37.3?; (3) Aged > 18 years. 2 Inclusion Criteria for the Control Group For the control group, clinical data were collected retrospectively. Enrollment was permitted only when the following symptoms, signs, laboratory test results, cytopathological data and imaging findings were all documented in the medical records: (1) Patients confirmed as malignant tumor cases by pathology or cytology; (2) Body temperature > 37.3? documented in the medical records; (3) Aged > 18 years; (4) Availability of complete blood count (white blood cell count), procalcitonin (PCT), C-reactive protein (CRP), culture results of the infected site, blood culture results and imaging findings in the medical records; (5) Availability of medication administration records in the medical records; (6) Availability of documented patient outcomes in the medical records.

Exclusion criteria

Exclusion criteria: 1. Patients not confirmed as malignant tumor cases by pathology or cytology; 2. Absence of fever; 3. Inability to cooperate in providing qualified blood samples.

Design outcomes

Primary

MeasureTime frame
Microbial Species Identified by Blood tNGS;Therapeutic duration and disease outcomes for imaging-confirmed fever in both the experimental and control groups.;

Countries

China

Contacts

Public ContactLi Ning

Cancer Hospital, Chinese Academy of Medical Sciences

mzbgd_0@sina.com+86 139 1122 8723

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026