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Heterogeneity of symptom clusters in childhood cancer survivors and related mechanisms of gut microbiota and gut metabolites

Heterogeneity of symptom clusters in childhood cancer survivors and related mechanisms of gut microbiota and gut metabolites

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600115999
Enrollment
Unknown
Registered
2026-01-04
Start date
2026-01-04
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer

Interventions

Children's Cancer Observation Group:None

Sponsors

Children's Hospital Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria for children with cancer: Age ranging from 8 to 18 years old; Patients diagnosed with cancer by clinical pathology (including leukemia, lymphoma, central nervous system tumors and other common solid tumors); Has entered the rehabilitation/maintenance treatment stage or has completed treatment for >=6 months; No cognitive impairment, and normal comprehension and communication skills. Sign the informed consent form before the start of the study and voluntarily participate in this research. Inclusion criteria for parents of children with cancer: Primary caregivers who meet the inclusion criteria of CCS in this study; Age >=20 years old; Be able to understand and answer questions, and have certain abilities in text reading and expression. Sign the informed consent form before the start of the study and voluntarily participate in this research.

Exclusion criteria

Exclusion criteria: Exclusion criteria for children with cancer: Severe treatment-related sequelae (such as severe organ dysfunction, neurological damage, etc.) that may interfere with symptom assessment; Poor cooperation, unable to independently complete interviews or fill out questionnaires; At the same time, participate in other intervention clinical trials that may affect the results of this study. During the research period, major surgeries or a new round of chemotherapy/radiotherapy are planned, which may affect the stable observation of the development trajectory of the symptom cluster. Exclusion criteria for parents of children with cancer: Having experienced major negative life events (such as widower or divorce) within the past six months, which may interfere with the assessment of psychological state; Combined with severe cognitive dysfunction; Combined with other special diseases such as severe aphasia and mental illness, it is impossible to complete the scale independently.

Design outcomes

Primary

MeasureTime frame
Sociodemographic data and clinical data;Incidence and severity of common symptoms;

Countries

China

Contacts

Public ContactJinhu Wang;Hongmei Wang

Children's Hospital Zhejiang University School of Medicine

wjh@zju.edu.cn+86 136 0663 6547

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026