Perioperative lung protection
Conditions
Interventions
Group A: Low PEEP Group (PEEP = 0 cmH2O):Group A: Low PEEP Group (PEEP = 0 cmH2O)
Group B: Medium PEEP Group (PEEP = 5 cmH2O) :Group B: Medium PEEP Group (PEEP = 5 cmH2O)
Group C: High PEEP Group (PEEP = 10 cmH2O):Group C: High PEEP Group (PEEP = 10 cmH2O)
Sponsors
Shihezi University First Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 75; 2. American Society of Anesthesiologists (ASA) class I-III; 3. Operation time >= 2 hours; 4.Understanding the study objectives and voluntarily signing the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiovascular and cerebrovascular diseases, pulmonary diseases, and airway diseases; 2.Patients who have not quit smoking or have quit smoking for less than 3 months; 3. Patients using catecholamine drugs, beta-blockers, theophylline, corticosteroids, or atropine; 4. Patients with severe nasal diseases or a history of nasal surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bronchial Mucus Transport Velocity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Saccharin Transit Time;Perioperative Pulmonary Complications;Hemodynamic indicators (blood pressure);Respiratory indicators (peak inspiratory pressure, plateau pressure, the ratio of peak expiratory flow rate to peak inspiratory flow rate, oxygenation index); | — |
Countries
China
Contacts
Public ContactSu Yifan
Shihezi University First Affiliated Hospital
Outcome results
None listed