Patients with endotracheal intubation or tracheotomy who have weak or absent cough reflexes
Conditions
Interventions
control group:The control group received standard airway clearance methods including chest physiotherapy, postural drainage, nebulized inhalation, induced cough, and suctioning.
intervention group:A mechanical cough machine (Respironics, Inc., E70) was used for the intervention group through applying mechanical insufflation-exsufflation to simulate physiologic cough for airwa
Sponsors
Hebei General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years; 2. Undergone tracheal intubation or tracheostomy; 3. Expected ICU stay >=7 day; 4. Absence of cough reflex as determined by lack of response to tracheal suctioning or pressure on the cricoid cartilage, yet presence of cough awareness or motion without effective sputum expulsion to the level of the vocal cords ; 5. Appropriate candidates for mechanical cough assist devices.
Exclusion criteria
Exclusion criteria: 1. End-expiratory positive pressure (PEEP) >10 cmH2O; 2. Fraction of inspired oxygen (FiO2) >0.7; 3. Hemodynamically unstable, defined as requiring norepinephrine infusion >0.25 ug/kg.min or needing intervention for arrhythmias; 4. Presence of pneumothorax, pulmonary bullae, or barotrauma; 5. Expected discontinuation of treatment or predicted survival less than 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Pulmonary Infection Score;blood gas indices;ICU Length of Stay;length of hospital stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of pulmonary infections; control of pulmonary infections; | — |
Countries
China
Contacts
Public ContactLiu Chunxia
Hebei General Hospital
Outcome results
None listed