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Effects of Different Doses of Nalbuphine on Sevoflurane MAC during Cervical Dilation in Patients Undergoing Hysteroscopic Surgery

Effects of Different Doses of Nalbuphine on Sevoflurane MAC during Cervical Dilation in Patients Undergoing Hysteroscopic Surgery

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600115970
Enrollment
Unknown
Registered
2026-01-04
Start date
2026-01-12
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hysteroscopic Surgery

Interventions

Group N1:Nalbuphine 0.1 mg/kg was administered intravenously prior to anesthesia induction.
Group N2:Nalbuphine 0.2 mg/kg was administered intravenously prior to anesthesia induction.
Group N3:Nalbuphine 0.4 mg/kg was administered intravenously prior to anesthesia induction.
Group C:An equivalent volume of normal saline was administered intravenously prior to anesthesia induction.

Sponsors

Guangyuan Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Inclusion criteria were as follows: patients scheduled for diagnostic or operative hysteroscopy, age range 20–45 years, ASA classification I–II.

Exclusion criteria

Exclusion criteria: 1. BMI >30 or <18 kg/m^2; 2. Refusal to sign the informed consent for the trial or inability to communicate; 3. Recent use of analgesics or sedatives, history of chronic pain, psychiatric disorders, alcohol or drug abuse; 4. Family history of malignant hyperthermia; 5. Patients allergic to opioids or inhalation anesthetics; 6. Patients with liver or kidney dysfunction; 7. Patients who have had vaginal delivery.

Design outcomes

Primary

MeasureTime frame
minimum alveolar concentration;

Secondary

MeasureTime frame
HR, MAP, BIS;Anesthesia Recovery Time ;Laryngeal Mask Airway (LMA) Removal Time;Aldrete Post-Anesthesia Recovery Score;Sedation-Agitation Scale Score;Face, Legs, Activity, Cry, Consolability Behavioral Pain Scale Score;Cumulative doses of propofol and sufentanil;Incidence of Adverse Events;

Countries

China

Contacts

Public ContactZhou Tao

Guangyuan Central Hospital

1808763922@qq.com+86 183 9879 0903

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026