Perioperative hypothermia and shivering
Conditions
Interventions
R group:Before anesthesia induction, remimazolam was intravenously pumped at a dose of 0.2 mg/kg. Then, anesthesia induction was performed using etomidate (0.1-0.3 mg/kg), sufentanil (0.3-0.5 µg/kg),
D group:Dexmedetomidine was intravenously pumped at a dose of 0.5 µg/kg before anesthesia induction, and the subsequent anesthesia induction was the same as that in the remimazolam group. During anest
C group:An equal amount of normal saline was intravenously pumped during induction and maintenance of anesthesia.
Sponsors
Chengdu Pidu District People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1 Aged 65-80 years, gender not limited; 2 Scheduled to undergo laparoscopic radical resection of gastrointestinal tumors under general anesthesia; 3 ASA grade II-III; 4 Patients are willing and able to provide a signed informed consent form before any study-related procedures are performed.
Exclusion criteria
Exclusion criteria: 1 Abnormal initial body temperature, such as = 37.5 °C; 2 Body Mass Index (BMI) > 30 kg/m^² or combined with diseases affecting body temperature, such as abnormal thyroid function, pituitary tumors, history of infectious fever within 2 weeks, etc.; 3 Expected operation time < 120 minutes; 4 History of severe cardiovascular, respiratory, liver or kidney dysfunction before surgery; 5 Allergy to remimazolam or dexmedetomidine; 6 Inability to cooperate in completing this study, such as mental illness, language difficulties, disturbance of consciousness, etc.; 7 Participation in other clinical trials within 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and severity of PAS 15 minutes after admission to the post-anesthesia care unit; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of hypothermia during surgery and in the PACU period;Core temperatures at multiple time points;The expression level of NE in serum; | — |
Countries
China
Contacts
Public ContactLi JunXiang
Chengdu Pidu District People's Hospital
Outcome results
None listed