Postoperative Nausea and Vomiting (PONV)
Conditions
Interventions
Control group: Metoclopramide:Metoclopramide
Experimental group: Metoclopramide + Transcutaneous Auricular Vagus Nerve Stimulation (taVNS): Metoclopramide + Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.American Society of Anesthesiologists (ASA) physical status classification I to III; 3.Scheduled for elective gynecological laparoscopic surgery under general anesthesia; 4.Provided informed consent signed by the patient or her legal guardian.
Exclusion criteria
Exclusion criteria: 1.Use of antiemetics, opioids, or corticosteroids within 3 days prior to surgery; 2.Refusal to sign the informed consent form; 3.Pregnancy or lactation; 4.Uncontrolled diabetes mellitus, severe coagulation dysfunction, or cardiac, central nervous system, or psychiatric diseases; 5.Implanted cardiac pacemaker or metal implants in the ear (to avoid interference with electrical stimulation); 6.Known allergy to palonosetron or dexamethasone; 7.Presence of nausea, vomiting, or both within 24 hours before surgery; 8.Presence of rash or local infection in the area of the ear designated for electrical stimulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative nausea and vomiting incidence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of first occurrence of postoperative nausea and vomiting;Number of vomits;Number of retching episodes;Nausea Severity;Use of rescue antiemetics;Postoperative pain score;Opioid consumption;Quality of postoperative recovery;Indicators of gastrointestinal function recovery; | — |
Countries
China
Contacts
Public ContactWang Ru
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed