Advanced Central Squamous Cell Lung Carcinoma with Airway Stenosis Failing Chemoradiotherapy
Conditions
Interventions
Advanced Central Squamous Cell Lung Carcinoma with Airway Stenosis:None
Sponsors
Huzhou Center Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–90 years; 2.Clinically, histopathologically, and radiologically (CT) confirmed diagnosis of advanced-stage central squamous cell lung carcinoma (SCC) with concurrent airway stenosis; TNM stage III or IV; patients deemed ineligible for or refusing surgical resection; 3.At least one measurable target lesion (per RECIST 1.1 or similar standard criteria); 4.Intolerance to chemoradiotherapy or documented disease progression following chemoradiotherapy; 5.Life expectancy > 3 months; 6.Provision of written informed consent after being fully informed about the study.
Exclusion criteria
Exclusion criteria: 1.Pregnancy, lactation, or planned pregnancy in patients of childbearing potential; 2.Severe cardiac, pulmonary, hepatic, or renal insufficiency; or clinically significant uncorrectable coagulopathy; 3.Extensive or uncontrolled extrapulmonary metastatic disease; 4.Concurrent active malignancy of another organ system or severe systemic immune disorder; 5.Contraindications to vascular intervention, bronchoscopic intervention, or iodinated contrast media; 6.Severe uncontrolled recurrent infections or other significant uncontrolled comorbidities; 7.Concurrent participation in another clinical trial or any other condition deemed unsuitable for enrollment by the investigator (due to safety concerns or protocol non-adherence);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in Airway Stenosis;Control of Airway Hemorrhage;;Oncologic Treatment Efficacy;Control of Airway Hemorrhage; | — |
Countries
China
Contacts
Public ContactShen Bin
Huzhou Center Hospital
Outcome results
None listed