Study on the Mechanism of Escherichia coli Lipopolysaccharide Inducing CD8+ T Cell Exhaustion in Colorectal Cancer

Study on the Mechanism of Escherichia coli Lipopolysaccharide Inducing CD8+ T Cell Exhaustion in Colorectal Cancer via Specific Vesicle Capture

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600115903

Enrollment

Unknown

Registered

2026-01-04

Start date

2026-01-04

Completion date

Unknown

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer

Interventions

Colorectal cancer patients group:None

Healthy subjects group:None

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients with colorectal cancer must have pathological confirmation and provide informed consent signed by themselves or their legal representatives; 2.Healthy controls must have colonoscopy results showing no intestinal lesions and provide informed consent signed by themselves or their legal representatives;

Exclusion criteria

Exclusion criteria: 1.Patients with major comorbid cardiovascular, cerebrovascular, respiratory, or other systemic diseases; 2.Patients with poorly controlled chronic conditions such as hypertension or diabetes; 3.Patients with other intestinal diseases such as Crohn's disease or ulcerative colitis; 4.Patients with psychiatric disorders or cognitive/communication impairments;

Design outcomes

Primary

Measure	Time frame
Fecal Lipopolysaccharide Expression;CD8? T Cell Exhaustion Markers Expression;	—

Countries

China

Contacts

Public ContactChu Jian

Huzhou Center Hospital

chujian980218@163.com+86 572 255 5233

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026