Kidney transplant
Conditions
Interventions
Cipropofol group, Group C:Anesthesia induction: Cisapride 0.4 mg/kg IV
Anesthesia maintenance: propofol 0.3~1.0 mg·kg-1·h-1 IV,with BIS maintained at 40-60 during the operation.
Fospropofol disodium group, Group F:Anesthesia induction: Fospropofol disodium 20 mg/kg IV
Anesthesia maintenance: Fospropofol disodium 0.3~1.0 mg·kg-1·h-1 IV,with BIS maintained at 40-60 during the operation.
Propofol group, Group P:Anesthesia induction: Propofol 2 mg/kg IV
Anesthesia maintenance: Propofol 4~12 mg·kg-1·h-1 IV,with BIS maintained at 40-60 during the operation.
Sponsors
The Second Affiliated Hospital of Guangxi Medical
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing their first cadaveric kidney transplantation; (2) Gender unrestricted, ASA classification III–IV, aged 18–60 years; (3) BMI 18–30 kg/m^2; (4) Regular preoperative dialysis treatment; (5) Capable of comprehending the study's procedures and methodologies, willing to sign the informed consent form, and strictly adhering to the clinical research protocol to complete the study.
Exclusion criteria
Exclusion criteria: (1) Suffering from liver, mental and nervous system diseases; (2) Coagulation dysfunction, heart failure, respiratory failure; (3) Long term use of sedative or antidepressant drugs; (4) Pregnant or lactating women; (5) Unable to communicate and cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure, Heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Urea, creatinine, cystatin C, glomerular filtration rate; | — |
Countries
China
Contacts
Public ContactWu Jiangdong
The Second Affiliated Hospital of Guangxi Medical University
Outcome results
None listed