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Evaluating the Utility of Arterial and Venous Watershed Localization Methods for Intraoperative Localization of Nonpalpable Pulmonary Nodules

Evaluating the Utility of Arterial and Venous Watershed Localization Methods for Intraoperative Localization of Nonpalpable Pulmonary Nodules

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115862
Enrollment
Unknown
Registered
2025-12-31
Start date
2026-01-20
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Nodules

Interventions

CT-guided localization group:None
Venous watershed analysis group:None
Arterial watershed analysis group:None

Sponsors

The affiliated people's hospital of Ningbo University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients who underwent pulmonary wedge resection at Ningbo University Affiliated People's Hospital between May 1, 2023, and December 1, 2025, and were preoperatively suspected of having non-palpable lung nodules (intraoperatively unlocatable by palpation); 2. Nodule diameter of 8-20 mm, with imaging indicating location in the peripheral one-third of the lung field; 3. Preoperative chest CT showing a ground-glass opacity (GGO) component >=50% in the nodule, or preoperative biopsy pathology confirming preinvasive lesions (such as atypical adenomatous hyperplasia or adenocarcinoma in situ); 4. Preoperative high-quality chest CT examination performed (1 mm slice thickness, end-inspiratory breath-hold scan), sufficient for three-dimensional reconstruction; 5. Complete medical records including preoperative examination reports, operative notes, postoperative nursing records, and pathological reports, with no critical data missing.

Exclusion criteria

Exclusion criteria: 1. History of severe underlying lung disease, including pneumoconiosis, active pulmonary tuberculosis, chronic obstructive pulmonary disease (COPD, pulmonary function class >= II), pulmonary fibrosis, etc.; 2. Allergy to iodine contrast agent or indocyanine green (ICG), or a history of severe drug allergy; 3. Patients requiring segmentectomy or lobectomy due to nodule characteristics (e.g., suspected invasive carcinoma with diameter >20 mm) or location (e.g., near the hilum); 4. History of previous ipsilateral lung surgery (e.g., lobectomy or segmentectomy), or conditions such as pleural adhesions or thoracic deformity that impair surgical procedure; 5. Patients with severe concomitant dysfunction of vital organs (heart, liver, kidney) or coagulation disorders rendering them unfit for surgery; 6. Incomplete medical records, such as missing documentation of localization time, complications, or pathological results.

Design outcomes

Primary

MeasureTime frame
Success rate of localization;Total hospitalization costs;

Secondary

MeasureTime frame
Length of hospital stay;Localization-associated complications;Localization procedure time;Total postoperative drainage volume;Final pathological diagnosis;Chest tube indwelling times;

Countries

China

Contacts

Public ContactHuang Wei

The affiliated people's hospital of Ningbo University

huangkeimeng@163.com+86 574 87106919

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026