Critically ill patients requiring continuous renal replacement therapy
Conditions
Interventions
600 ml of Sodium Citrate Solution for Anticoagulation (200 ml: 8 g) + 4 L of Replacement Fluid for Standard CRRT (Citrate Concentration Approximately 18 mmol/L):600 ml of Sodium Citrate Solution for A
Control group:Standard CRRT replacement fluid
Sponsors
Henan Provincial People's Hospita,medical
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.High-risk bleeding patients with CRRT treatment duration >= 24 hours; 3.The patient's family members have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Severe liver dysfunction; 2.severe hypoxemia or insufficient tissue perfusion; 3.known history of allergy or severe intolerance to sodium citrate; 4.severe uncorrected hypocalcemia; 5.pregnant or lactating women; 6.participation in other clinical trials that may interfere with the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemoglobin;Coagulation function;Filter lifespan;Platelet; | — |
Secondary
| Measure | Time frame |
|---|---|
| Calcium ions after the filter;Citrate accumulation;Liver function;Bleeding complications;Blood gas;Electrolyte; | — |
Countries
China
Contacts
Public ContactZhang Hongtao
Henan Provincial People's Hospita,medical
Outcome results
None listed