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Mechanisms and Therapeutic Targeting of CD169? Osteomac-Driven Immuno–Neuronal Interactions in the Promotion of Osteoarthritis Pain

Mechanisms and Therapeutic Targeting of CD169? Osteomac-Driven Immuno–Neuronal Interactions in the Promotion of Osteoarthritis Pain

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115844
Enrollment
Unknown
Registered
2025-12-31
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

Lateral control region:None
Medial OA region:None

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria; 2.Age between 60 and 80 years; 3.Persistent knee pain for at least 6 months; 4.Typical radiographic or MRI changes consistent with knee osteoarthritis.

Exclusion criteria

Exclusion criteria: 1.Presence of other types of arthritis (e.g., rheumatoid arthritis, gouty arthritis); 2.Presence of other conditions causing knee pain (e.g., hip disorders, lumbar spine disorders); 3.Underwent knee surgery or intra-articular injection treatment within the past 3 months.

Design outcomes

Primary

MeasureTime frame
CCL8 expression level;—

Secondary

MeasureTime frame
CCR8/HCN2 expression level;—

Countries

China

Contacts

Public ContactXu Langhai

Zhejiang Provincial People's Hospital

xulanghai1991@163.com+86 10 1234 5678

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026