hypertrophic cardiomyopathy (HCM)
Conditions
Interventions
No-SGLT2i group vs SGLT2 inhibitor treatment group:NA
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Meets the diagnostic criteria for HCM (based on echocardiography/cardiac MRI: left ventricular wall thickness >=15 mm in any segment after excluding other loading conditions; or >=13 mm in the presence of family history/pathogenic gene positivity); 3. Has accessible baseline clinical data (demographic information, medical history, physical examination, laboratory and imaging results); 4. Has clear records of SGLT2 inhibitor use and duration of medication, or a clear indication of no use of SGLT2 inhibitors.
Exclusion criteria
Exclusion criteria: 1. Myocardial hypertrophy clearly caused by other diseases (such as severe hypertensive heart disease, amyloidosis, Fabry disease, athlete's heart hypertrophy, etc.); 2. Presence of other clearly diagnosed cardiomyopathies (such as restrictive, dilated, myocarditis, etc.); 3. Presence of moderate to severe valvular heart disease or congenital heart disease; 4. Acute myocardial infarction, cardiac surgery, or transcatheter valve intervention within 3 months prior to enrollment; 5. Presence of malignant tumors, severe liver or kidney failure, active infections, or other diseases with an expected survival of less than 1 year; 6. Baseline eGFR < 15 ml/min/1.73m² or end-stage renal disease (dialysis/kidney transplantation); 7. Severe missing baseline data, making it impossible to complete key covariate matching or primary endpoint analysis; 8. Percutaneous alcohol ablation or surgical myectomy within 3 months prior to enrollment and still in the acute recovery phase (can be re-included in sensitivity analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause death;Composite endpoint event: All-cause death or first hospitalization for heart failure (whichever occurs first).;First hospitalization for heart failure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Renal and metabolic parameters;Arrhythmia events;Individual clinical events: All-cause death, cardiovascular death, first hospitalization for heart failure, and all-cause rehospitalization.;Imaging parameters; | — |
Countries
China
Contacts
Public ContactRong Jiang
Shanghai General Hospital
Outcome results
None listed