Premature infant infection, necrotizing enterocolitis (NEC), and retinopathy of prematurity
Conditions
Interventions
Donation to Breastfeeding Group:Donate breastfeeding for one week
Maternal reinforcement donation of breast milk (including 10% maternal breast milk) feeding group:Feed for one week with mother reinforced donated breast milk (including 10% mother's breast milk)
Sponsors
Hangzhou Women's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for mother and breast milk: 1. Fresh colostrum can be provided for research purposes; 2. Healthy body and balanced diet structure. Inclusion criteria for premature infants: 1. Admission was based on the American Academy of Pediatrics (AAP) guidelines; 2. 28 weeks <= gestational age <= 37 weeks; 3. Admitted to our NICU at birth; 4. Open milk within 24 hours after entering the clinic; 5. All guardians of the research subjects signed informed consent forms.
Exclusion criteria
Exclusion criteria: Exclusion criteria for mother and breast milk: 1. Smoking and alcohol consumption during lactation; 2. During lactation, there may be local infections in the nipple and areola, mastitis, or severe systemic infections; 3. Treatment with antibiotics and psychotropic drugs during lactation; 4. Postpartum depression. Exclusion criteria for premature infants: 1. those with severe liver, liver, and kidney dysfunction; 2. Congenital malformation patients; 3. Individuals with congenital inherited metabolic and chromosomal diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabolomics;short-chain fatty acids;gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional and health status of premature infants; | — |
Countries
China
Contacts
Public ContactFei Yang
Hangzhou Women's Hospital
Outcome results
None listed