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Inhibition of mitochondrial cholesterol transporter PDZD8 by manganese ions reverses CD8+T cell exhaustion in high cholesterol colorectal cancer

Inhibition of mitochondrial cholesterol transporter PDZD8 by manganese ions reverses CD8+T cell exhaustion in high cholesterol colorectal cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115835
Enrollment
Unknown
Registered
2025-12-31
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Sponsors

Huzhou Center Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Inclusion criteria for colorectal cancer patients: a. Patients pathologically diagnosed with colorectal cancer; b. Normal individuals with no positive lesions detected by colonoscopy; c. The patient or their legal representative has signed the informed consent form. (2) Inclusion criteria for healthy individuals: a. Colonoscopy results show no intestinal lesions; b. The individual or their legal representative has signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients with heart, brain, blood vessel, respiratory system and other major diseases; 2.Patients with chronic diseases such as hypertension and diabetes; 3.Patients with Crohn's disease, ulcerative colitis and other intestinal diseases; 4.Patients with mental illness or cognitive or communication dysfunction;

Design outcomes

Primary

MeasureTime frame
Peripheral blood Mn2+ level, serum cholesterol and mitochondrial damage index;

Secondary

MeasureTime frame
Mn2 levels, PDZD8 expression, and cholesterol levels in CD8+ T cells;

Countries

China

Contacts

Public ContactYang Xi

Huzhou Center Hospital

yangxi19900601@126.com+86 572 255 5316

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026