Patients undergoing laparoscopic surgery?
Conditions
Interventions
Propofol Group:Induction with propofol 2.0 mg/kg, maintenance with continuous infusion of propofol 4.0-10.0 mg/(kg·h), maintaining BIS between 40-60.
Ciprofol Group:Induction with ciprofol 0.4 mg/kg, maintenance with continuous infusion of ciprofol 0.8-1.5 mg/(kg·h), maintaining BIS between 40-60.
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Signed informed consent; 2. Patients scheduled for elective laparoscopic surgery; 3. Patients with ASA physical status I-III; 4. Patients aged 18-70 years; 5. Patients with BMI between 18-28 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiopulmonary dysfunction; 2. Patients with severe hepatic or renal insufficiency; 3. Patients with anticipated difficult airway; 4. Patients with known allergy or contraindication to any drug used in this study; 5. Patients with neurological/psychiatric disorders or long-term use of hypnotics/sedatives; 6. Patients who are pregnant, lactating, or planning pregnancy; 7. Patients with cognitive impairment unable to cooperate with the 24-hour postoperative QoR-15 score assessment; 8) Other conditions deemed by the investigator as unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Recovery-15 (QoR-15) score on the first postoperative day; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 score on the second postoperative day;Perioperative hemodynamic changes;Intraoperative use of vasoactive drugs;Dosage of study drugs;Time required for BIS <=60 after induction with the study drug;Extubation time;PACU length of stay;Incidence of other perioperative adverse events (e.g., intraoperative awareness, nausea and vomiting, postoperative fever, postoperative delirium, drowsiness, allergy) ;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactCheng Hao
The First Affiliated Hospital of Soochow University
Outcome results
None listed