Osteoarthritis of knee joint
Conditions
Interventions
Control group Dex group:A total of 30ml of 0.25% bupivacaine hydrochloride supplemented with 5mg dexamethasone as adjuvant was used for popliteal artery and knee posterior capsular space block (IPack
Trial group BL group:A total of 30ml of 20ml (266mg) liposomal bupivacaine was mixed with 10ml of 0.25% bupivacaine hydrochloride injection, and the block was performed in the popliteal artery and pos
Sponsors
Beijing Anzhen Hospital Affiliated to Capital Medical University Nanchong Hospital & Nanchong Central Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: A total of 60 patients undergoing primary unilateral total knee arthroplasty for the first time between December 2025 and early May 2026 were selected, with ASA class II–III and ages ranging from 55 to 80 years.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of allergy to bupivacaine or other local anesthetics. 2.Abnormal liver and kidney functions, diabetes mellitus and poor blood glucose control (fasting blood glucose > 7.0mmol/l) 3.Patients with lumbar disc herniation accompanied by lower limb neurological symptoms or those with a history of lower limb peripheral nerve injury. 4. Patients with conduction block or ventricular arrhythmia indicated by ECG. 5. Patients who are blind or deaf and cannot complete the visual analogue scale of pain. 6.Patients with severe liver dysfunction and confirmed liver cirrhosis accompanied by abnormal liver enzymes. 7. Patients who refuse to participate in the experiment or cannot complete the experiment for some reason. 8. Patients with a family history of malignant hyperthermia or a history of malignant hyperthermia. 9. Those with a history of mental and neurological diseases, alcohol and drug abuse, and long-term use of opioid analgesics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue pain score 12 hours after surgery;Visual analogue pain score 24 hours after surgery;Visual analogue pain score 48 hours after surgery;Visual analogue pain score 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Mobility Recovery: Time to first ambulation (since the end of surgery), muscle strength recovery;Postoperative Analgesia-Related Adverse Reactions: Presence of nausea and vomiting, decreased oxygen saturation, muscle weakness, nerve injury;Blood Glucose Levels;Long-term Follow-up: Total hospital stay, joint mobility, long-term nerve injury, and other indicators; | — |
Countries
China
Contacts
Public ContactRen Pusheng
Beijing Anzhen Hospital Affiliated to Capital Medical University Nanchong Hospital & Nanchong Central Hospital
Outcome results
None listed