Postoperative nausea and vomiting
Conditions
Interventions
Propofol group:Anesthesia was induced with propofol at 2 mg/kg.
Fospropofol disodium group:Anesthesia was induced with fospropofol disodium at a dose of 10 mg/kg.
Ciprofol group:Anesthesia was induced with ciprofol at a dose of 0.5 mg/kg.
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Female patients aged 18 to 65 years; (2) American Society of Anesthesiologists (ASA) physical status classification I to III; (3) Scheduled for elective laparoscopic cholecystectomy under general anesthesia; (4) Non-smoker (defined as no use of any tobacco products within the past 6 months); (5) Provision of signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with known allergy or contraindications to propofol, fospropofol disodium, ciprofol, or any of their components; (2) History of severe hepatic, renal, pulmonary, or cardiac disease; (3) Pregnant or lactating women; (4) History of chronic nausea and vomiting; (5) History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis before surgery; (6) History of nausea and vomiting or use of antiemetic medications within 24 hours prior to surgery; (7) Patients deemed by the investigator to be unsuitable for inclusion in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The overall incidence of PONV in the PACU during the postoperative period; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of episodes of nausea and vomiting in the PACU postoperatively, along with the frequency and dosage of rescue antiemetic medications administered.;Severity of postoperative nausea and vomiting in the PACU;Number of episodes and incidence of nausea or vomiting within 24 hours after surgery;Adverse reactions during induction, duration of surgery, time to awakening, extubation time, and length of stay in the PACU;Blood concentrations of propofol/ciprofol at the end of surgery, 30 minutes after entering the PACU, and upon discharge from the PACU;Incidence of intraoperative hypotension and bradycardia; | — |
Countries
China
Contacts
Public ContactXiaoqiang Li
West China Hospital of Sichuan University
Outcome results
None listed