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The curative effect and underlying brain mechanisms of different targets repetitive transcranial magnetic stimulation treatment for post-stroke depression

The curative effect and underlying brain mechanisms of different targets repetitive transcranial magnetic stimulation treatment for post-stroke depression

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500115818
Enrollment
Unknown
Registered
2025-12-31
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke depression

Interventions

Experimental group 1:Application of iTBS to left DLPFC (precise localize the center of middle frontal gyrus)
Experimental group 2:Application of iTBS to left DLPFC (5-cm localization method)
Sham group:Sham stimulation

Sponsors

Affiliated Hospital of Hangzhou Normal University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.diagnosis of stroke by neurologists; 2.first-time ischemic stroke, admitted < 6 months after stroke onset; 3.unilateral focal brain lesions; 4.diagnosed in conformity with the DSM-V diagnostic criteria; 5.NIHSS <15; 6.no contraindications to MRI scan and rTMS treatment;

Exclusion criteria

Exclusion criteria: 1.brain dysfunction caused by other non-vascular causes; 2.history of depression, dementia and other psychiatric diseases; 3.MMSE < 19; 4.no show in the follow-up visit; 5.TIA or subarachnoid hemorrhage; 6.history of other neurologic diseases;

Design outcomes

Primary

MeasureTime frame
Functional brain metrics;Depression scales;—

Countries

China

Contacts

Public ContactYating Lv

Affiliated Hospital of Hangzhou Normal University

lvyating@hznu.edu.cn+86 571 88303417

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026