Mild Cognitive
Conditions
Interventions
Normal cognitive control group:None
Sponsors
Fujian University of Traditional Chinese Medicine Rehabilitation Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for Mild Cognitive Impairment (MCI) or cognitively normal older adults with a Montreal Cognitive Assessment (MoCA) score =26; 2. Aged >=60 years; right-handed (assessed using the Edinburgh Handedness Inventory); 3. Provide informed consent and voluntarily participate.
Exclusion criteria
Exclusion criteria: 1.Participants with a score >=9 on the Short Geriatric Depression Scale (GDS-15). 2.Patients diagnosed with dementia of any etiology. 3.Individuals with cognitive impairment caused by other conditions, including medication use (e.g., antipsychotics, benzodiazepines), intoxication, inflammatory cerebrovascular disease, encephalitis, brain tumors, traumatic brain injury, epilepsy, or Parkinson’s disease. 4.Patients with severe cardiac, hepatic, or renal failure, malignant tumors, or other major systemic illnesses. 5.Individuals with severe visual, auditory, or speech impairments that preclude valid cognitive assessment. 6.Participants with contraindications to MRI scanning (e.g., cardiac pacemakers, coronary stents, fixed dental prostheses, metal implants, claustrophobia, or febrile conditions). 7.Individuals who have taken prokinetic agents, laxatives, or other medications affecting gastrointestinal motility within the past month; or who have used antibiotics, probiotics, or prebiotics within the past month. 8.Patients with gastrointestinal diseases such as irritable bowel syndrome, ulcerative colitis, Crohn’s disease, or intestinal tumors. 9.Patients with poorly controlled hypertension (systolic BP >160 mmHg or diastolic BP >100 mmHg despite medication). 10.Participants currently enrolled in other clinical trials that may interfere with the outcomes of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive impairment;Fuzhou Version of the Montreal Cognitive Assessment (MoCA);Wechsler Memory Scale Test;Rey Auditory Verbal Learning Test,RAVLT;Rey-Osterrieth Complex Figure Test ,ROCF;Digital symbols transformation test,DST;Trail Making Test B,TMT B;Stroop Color-Word Card Test;Food frequency questionnaire,FFQ25;24-Hour Dietary Recall Scale; | — |
Countries
China
Contacts
Public ContactWu Lixin
Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine
Outcome results
None listed