Hepatic dysfunction complicated with pneumonia and urinary tract infection
Conditions
Interventions
Model-guided Group:Following randomization, a 7-day observation period was established. For each patient, blood samples were required to be collected within 24 hours after the initial administration t
Standard-Dose Group: a. CFP-SUL: Administered at a dose of 2 g/1 g via intravenous infusion every 12 hours. b.LVFX: Given as 500 mg through intravenous infusion once a day. The duration of treatment s
Sponsors
Chun' an County First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Aged 18 years or older. (2) Diagnosed with community- or hospital-acquired pneumonia complicated by urinary tract infection according to the *Guidelines for the Diagnosis and Management of Infectious Pneumonia in Adults* and the *Chinese Expert Consensus on the Diagnosis and Treatment of Urinary Tract Infections*. (3) Hepatic impairment classified as Child–Pugh B or C. (4) Willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: (1) History of hypersensitivity or resistance to cefoperazone–sulbactam or levofloxacin. (2) Pregnant or lactating women. (3) Severe renal impairment (GFR < 30 mL/min). (4) Concomitant use of drugs that may affect drug metabolism (e.g., potent CYP inhibitors/inducers). (5) Participation in other clinical trials. (6) Presence of other severe comorbidities. (7) History of drug abuse or dependence. (8) Complications such as respiratory failure or sepsis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Patients Successfully Receiving Intended Treatment;Number of Treatment Failures;Time from Treatment to Clinical Cure Hospitalization;Number of Patients with Clinical Cure within 7 Days;Pneumonia Improvement Time;Urinary Tract Infection Improvement Time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Reasons for Treatment Failure;Attainment Rate of freee time(fT)>MIC Target;Incidence of Adverse Events; | — |
Countries
China
Contacts
Public ContactWang Zhirou
Chun'an County First People's Hospital
Outcome results
None listed