Breast cancer with lung metastasis
Conditions
Interventions
Breast cancer with lung metastasis:Not applicable
Sponsors
Chongqing General Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Presence of distant metastasis at the time of breast cancer diagnosis (confirmed by imaging and/or pathology, with diagnosis of metastatic lesions within =6 months following surgery; 2.Lung as the primary site of disease progression, with histological confirmation of invasive breast carcinoma (excluding carcinoma in situ); 3.Conscious, without psychiatric disorders, with good compliance, and able to adhere to medical advice for treatment and follow-up; 4.Voluntary participation in this study with the ability to provide written informed consent;
Exclusion criteria
Exclusion criteria: 1.Concomitant primary malignancies other than breast cancer, or severe autoimmune diseases (e.g., systemic lupus erythematosus, rheumatoid arthritis). 2.Severe hepatic or renal impairment (ALT/AST >3× upper limit of normal, creatinine >1.5× upper limit of normal) or cardiac/pulmonary failure (NYHA functional class >=III); 3.History of atopy or known/suspected allergy to study-related agents; 4.Pregnancy or lactation, or the presence of psychiatric illness, cognitive impairment, or other conditions that preclude compliance with study procedures;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association between characteristic microbial biomarkers and prognosis (PFS, OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between microbial biomarkers and immune microenvironment;Predictive value of combined microbial biomarker model; | — |
Countries
China
Contacts
Public ContactChong Li
Chongqing General Hospital
Outcome results
None listed