Autism spectrum disorder
Conditions
Interventions
ASD group:Revised Intervention (ASD Group and Healthy Control Group):The sulforaphane intervention was changed to Zhiyinguosu? Tablets (Concentrated Formula), manufactured by Shenzhen Fushan Biotechno
Health group:Revised Intervention (ASD Group and Healthy Control Group):The sulforaphane intervention was changed to Zhiyinguosu? Tablets (Concentrated Formula), manufactured by Shenzhen Fushan Biotec
Sponsors
Second Xiangya Hospital of CSU
Eligibility
Sex/Gender
All
Age
12 Years to 34 Years
Inclusion criteria
Inclusion criteria: ASD group: 1. age 12-34 years old; 2. It conforms to the diagnosis of autism spectrum disorder in the Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (DSM-V) of the United States; 3. It conforms to the diagnosis of autism diagnostic interview-revised (ADI-R) autism spectrum disorder; 4. autism spectrum disorder's diagnosis is in accordance with the autism diagnostic observation schedule (ADOS). Healthy control group: 1. age 12-34 years old; 2. Does not meet diagnostic criteria for any mental disorder.
Exclusion criteria
Exclusion criteria: ASD group: 1. there are serious physical diseases and conditions, such as congenital heart disease, thyroid disease, liver and kidney dysfunction, audio-visual impairment, etc.; 2. Accompanied by serious nervous system diseases, with a clear family history or potential risks, such as brain trauma, encephalitis, epilepsy, febrile convulsions, birth injuries, abnormal EEG, etc.; 3. There are definite or suspicious hereditary diseases, such as trisomy 21 syndrome and fragile X syndrome; 4. It conforms to the diagnosis of other developmental diseases, such as simple mental retardation, simple language development disorder, selective mutism, etc. 5. Meet the diagnosis of other severe mental diseases, such as schizophrenia and bipolar disorder; 6. Taking other drugs in psychiatry and neurology. Healthy control group: Exclusion criteria consistent with the ASD group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Ohio State University Autism Rating Scale for DSM-5 (OARS-5); | — |
Secondary
| Measure | Time frame |
|---|---|
| Altman Self-Rating Mania Scale (ARSM);Eye tracker measurement;SAFETE;Diagnostic criteria for autism assessment in Oregon State University-DSM-V;Inventory of Callous-Unemotional Traits (ICU);CGI Severity of Autism Impression Scale;Autism Spectrum Quotient-10 (AQ-10);electroencephalogram;Wendi Utah Adult ADHD Self-rating Scale;Camouflaging Autistic Traits Questionnaire (CAT-Q);DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure—Adult (CCSM-Adult);Raven intelligence test;Test Of Attentional Performance;Behavioral Inhibition System/Behavioral Activation System Scales (BIS/BAS Scales);The Sensory Perception Quotient-10 (SPQ-10);Magnetic Resonance Imaging;Athens Insomnia Scale (AIS);The Systemizing Quotient-Revised-10 (SQ-R-10);Interpersonal Reactivity Index (IRI);Autism Treatment Evaluation Checklist (ATEC);Improvement of CGI of Autism Impression Scale;Patient Health Questionnaire-9 (PHQ-9);Adult ADHD Self-Report Scale-5 (ASRS-5);Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A);The Empathy Quotient-10 (EQ-10);Borderline Symptom List-23 (BSL-23);Child Behavior Checklist (CBCL);Generalized Anxiety Disorder-7 (GAD-7); | — |
Countries
China
Contacts
Public ContactJianjun Ou
Second Xiangya Hospital of CSU
Outcome results
None listed