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The role of dopamine and abnormal iron metabolism in acute ischemic stroke related restless legs syndrome: a prospective nested case-control design

The role of dopamine and abnormal iron metabolism in acute ischemic stroke related restless legs syndrome: a prospective nested case-control design

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115796
Enrollment
Unknown
Registered
2025-12-31
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ischemic stroke related restless legs syndrome

Interventions

Case group:none

Sponsors

Shanghai General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosis of acute ischemic stroke (AIS) : diagnosed as acute ischemic stroke according to the WHO definition, within 14 days of onset; 2. Age limit: age between 18 and 80 years old (18.0<= age <=80); 3. FDOPA-PET and/or SWI examinations have been completed; 4. Informed consent: patients could understand the content of the study and signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Unable to cooperate with the questionnaire evaluation due to altered consciousness, aphasia, cognitive impairment, etc; 2. Patients with uncontrolled diabetic peripheral neuropathy, severe iron deficiency, renal failure, obstructive sleep apnea syndrome; 3. Current use of antidepressants or other medications that may cause sleep-related movement disorders (e.g., a. Tricyclic antidepressants; b. Serotonin reuptake inhibitors; c. antidopaminergic drugs; d. antipsychotic drugs, etc.), severe mental illness, etc;

Design outcomes

Primary

MeasureTime frame
Striatal dopamine Standardized Uptake Value Ratio;

Secondary

MeasureTime frame
Magnetic susceptibility values of nucleus;

Countries

China

Contacts

Public ContactWang xixi

Shanghai General Hospital

1627974588@qq.com+86 21 6324 0090

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026