Benign Prostatic Hyperplasia (BPH)
Conditions
Interventions
Experimental group:Induction regimen: Ciprofol 0.4 mg/kg + Sufentanil 0.4 µg/kg
Maintenance regimen: Ciprofol infusion at 0.8 mg/(kg·h).
Control group:Induction regimen: Propofol 2 mg/kg + Sufentanil 0.4 µg/kg
Maintenance regimen: Propofol infusion at 4 mg/(kg·h).
Sponsors
Heji Hospital Affiliated to Changzhi Medical College
Eligibility
Sex/Gender
Male
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Demographics: Age >=65 years, male, BMI 18-30 kg/m^2; 2. Type of Surgery: Elective transurethral resection of the prostate (TURP), expected surgery duration >=1 hour; 3. Baseline Cognition: Preoperative MoCA score >=26 (excluding baseline cognitive impairment); 4. ASA Classification: I-III, Cardiac function NYHA I-II; 5. Informed Consent: Patient and family have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Comorbidities: Severe liver and kidney dysfunction (Child-Pugh class C or eGFR < 30 ml/min/1.73m^2); 2. Neurological diseases: History of Alzheimer's disease, Parkinson's disease, or stroke; 3. Medication use: Use of glucocorticoids, immunosuppressants, or antipsychotic drugs within 1 month before surgery; 4. Anesthesia contraindications: Allergies to propofol, etomidate, or opioids; 5. Others: Use of sedatives within 24 hours before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium at 7 days (CAM positivity rate); | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA);Serum GDNF level; | — |
Countries
China
Contacts
Public ContactChen Chi
Heji Hospital Affiliated to Changzhi Medical College
Outcome results
None listed