wound healing
Conditions
Interventions
Control group:NA
Scar wound group:NA
Sponsors
Shanghai Sixth People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Healthy Participants (1) Aged between 18 and 65 years (inclusive). (2) Voluntarily agreed to participate in the study and signed the informed consent form. (3) Availability of surplus skin tissue during debridement procedures. (4) No history of major infectious diseases (e.g., hepatitis B, human immunodeficiency virus [HIV] infection). (5) Non-scar-forming constitution, defined as a Vancouver Scar Scale (VSS) score of 0 . 2. Patients with Hypertrophic Scarring (1) Aged between 18 and 65 years (inclusive). (2) Pathologically confirmed diagnosis of hypertrophic scarring, with a VSS score > 5 . (3) No prior scar-related treatments (e.g., laser therapy, surgical excision) within 1 year before enrollment. (4) Voluntarily agreed to participate in the study and signed the informed consent form. (5) Availability of surplus scar tissue during debridement procedures.
Exclusion criteria
Exclusion criteria: Common Exclusion Criteria 1. Females who were pregnant or lactating. 2. Presence of coagulation dysfunction (e.g., international normalized ratio [INR] > 1.5 or activated partial thromboplastin time [APTT] > 1.5 times the upper limit of the normal reference range). 3. Administration of immunosuppressants or glucocorticoids within the preceding 6 months. 4. Comorbidities of severe cardiopulmonary diseases (e.g., New York Heart Association [NYHA] functional class ? or higher) or acute hepatic/renal failure. 5. Infected wounds or active infectious foci (evidenced by white blood cell [WBC] count > 12 × 10?/L or C-reactive protein [CRP] level > 10 mg/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in gene expression, signaling pathway activity, and histological features; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wound healing rate; | — |
Countries
China
Contacts
Public ContactCunyi Fan
Shanghai Sixth People’s Hospital
Outcome results
None listed