Pancreaticobiliary diseases
Conditions
Interventions
Experimental Group:Esketamine hydrochloride at a dose of 0.3 mg/kg was administered before the operation
Control group:Sufentanil at a dose of 0.1 µ g/kg was administered before the operation, while all other conditions remained unchanged.
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. All patients aged 65-80 who underwent ERCP 2. Patients scheduled for ERCP 3. Voluntarily sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Patients with a history of psychiatric disorders who are taking antipsychotic drugs or narcotic sedative and analgesic drugs; 2. Patients who are allergic to or have contraindications to anesthetic drugs such as propofol, opioids, and esketamine; 3. Use of concomitant medications prohibited in clinical trials of esketamine, which affect efficacy and safety assessments (such as aminophylline or theophylline); 4. Use drugs that affect the hepatic and renal metabolism of esketamine, such as hepatic enzyme inhibitors like chlorpromazine; 5. Patients with severe hepatic and renal dysfunction in the decompensation phase; 6. Have experienced unstable angina pectoris, myocardial infarction, or congestive heart failure within the past 6 months; 7. Patients with any of the following contraindications to the use of esketamine injection: 1) Patients with severe risk of elevated blood pressure or intracranial pressure; 2) Patients with high intraocular pressure (glaucoma) or penetrating ocular trauma; 3) Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic blood pressure over 180 mmHg, or resting diastolic blood pressure over 100 mmHg); 4) Patients with untreated or inadequately treated hyperthyroidism; 8. The researcher believes that there are any other reasons that make the patient unsuitable for participating in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of intestinal peristalsis and intestinal spasm;The time of the first exhaust, defecation, the first oral meal, and the first time to get out of bed and move around;Incidence of complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative cognitive dysfunction;Nausea and vomiting;Hypotension;Respiratory depression;The percentage of successful selective intubation;Intubation time;Measurement result; | — |
Countries
China
Contacts
Public ContactZhenzhou Li
General Hospital of Ningxia Medical University
Outcome results
None listed